Psychostimulant dependence is a major public health problem and no medications have been
shown to be very effective in treating this disorder. Thus, the investigators wish to study
whether a blood pressure drug thought to reduce drug craving through its interaction at
particular adrenergic receptors - doxazosin - can dredge cocaine use relative to placebo in
psychostimulant dependent participants enrolled in an 8-week, randomized, double blind,
placebo-controlled outpatient clinical trial. Our hypothesis is that doxazosin will reduce
cocaine use relative to placebo in psychostimulant dependent participants.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
University of Arkansas
Collaborators:
Baylor College of Medicine National Institute on Drug Abuse (NIDA)