Overview
Doxepin Solution for Alleviation of Stubborn Breakthrough Pain Induced by Swallowing in Patients Receiving Radiotherapy for Nasopharyngeal Carcinoma
Status:
Recruiting
Recruiting
Trial end date:
2024-09-15
2024-09-15
Target enrollment:
0
0
Participant gender:
All
All
Summary
The goal of this clinical trial is to explore the effectiveness and adverse reactions of doxepin solution spray for alleviation of stubborn breakthrough pain induced by swallowing in patients receiving radiotherapy for nasopharyngeal carcinoma.Phase:
N/AAccepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Nanfang Hospital, Southern Medical UniversityTreatments:
Doxepin
Criteria
Inclusion Criteria:1. Provide informed written consent.
2. Age ≥ 18 years.
3. Histologically confirmed as nasopharyngeal carcinoma, and currently undergoing radical
radiotherapy or chemoradiotherapy.
4. Physical examination demonstrating the presence of radiation-induced mucositis in the
oral cavity and/or oropharynx.
5. At least 4 (out of 10) patient-reported swallowing-induced pain as measured by the
numeric rating scale of pain.
6. Being able to complete the questionnaires independently or with assistance.
7. ECOG Performance Status 0, 1 or 2.
Exclusion Criteria:
1. Known allergy to doxepin, tricyclic antidepressants, or any known component of the
drug formulation.
2. Use of a tricyclic antidepressant or monoamine oxidase inhibitor within 14 days prior
to registration.
3. Current untreated or unhealed oral candidiasis or oral herpes simplex virus infection.
4. Untreated narrow angle glaucoma within 6 weeks prior to registration.
5. Untreated urinary retention within 6 weeks prior to registration.
6. Administration of cryotherapy to prevent oral mucositis within 6 weeks prior to
registration.
7. Current serious heart disease or a recent history of myocardial infarction.
8. Current untreated or unresolved conditions like epilepsy, hyperthyroidism, hepatic
dysfunction, delirium, and neutropenia.
9. Pregnant or lactating women.