Doxycycline and Airway Inflammation in Chronic Obstructive Pulmonary Disease (COPD)

• Status: Unknown status
• Trial end date: 2010-01-01
• Target enrollment: 0
• Participant gender: All

Summary

COPD is a progressive pulmonary disease that is characterized by an inflammatory process in the airways and the lungs which leads to progressive airway obstruction. The inflammation is associated with tissue loss and remodelling. The investigators hypothesized that doxycycline reduces neutrophilic airway inflammation in patients with COPD. Therefore the investigators will conduct a randomized trial of doxycycline in 30 patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Medical Center Alkmaar
• Collaborators: Leiden University Medical Center; Universiteit van Amsterdam; University of Amsterdam
• Treatments: Doxycycline

Criteria

Inclusion Criteria:

• GOLD II or III COPD (GOLD II: FEV1/FVC < 70%; 50% < FEV1 < 80% predicted, GOLD III:

FEV1/FVC < 70%; 30% < FEV1 < 50% predicted ).

• Stable disease (no exacerbations in the last 3 months).

• Age > 40 yrs.

• Written informed consent.

Exclusion Criteria:

• Infections and/or use of antibiotics in the last month.

• Bacterial colonization of the airways, proven by sputum cultures or broncho-alveolar lavage (BAL).

• Allergy for tetracyclines or a history of substantial side-effects.

• Active respiratory diseases other than COPD (e.g. sarcoidosis, tuberculosis, lung cancer, bronchiectasis).

• Acute exacerbation of COPD as defined by Anthonisen et al. [10].

• Signs and/or symptoms of a current respiratory or non-respiratory infection.

• Use of oral or intravenous corticosteroids or other immunosuppressive drugs within the last month.