Doxycycline for Lateral Elbow Tendinopathy

• Status: Recruiting
• Trial end date: 2022-01-01
• Target enrollment: 0
• Participant gender: All

Summary

To evaluate the feasibility of subantimicrobial -dose (SD) doxycycline to improve outcomes of nonsurgical management of lateral elbow tendinopathy via matrix metalloproteinase (MMP) inhibition as well as evaluate if participants will be compliant to with prescribed medication and exercise treatment. Our working hypothesis is that patients with lateral elbow tendinopathy will be receptive to treatment with SD-doxycycline and compliant with the prescribed treatment.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hospital for Special Surgery, New York
• Treatments: Doxycycline

Criteria

Inclusion Criteria:

• Males and females ages of 18-60

• Atraumatic unilateral elbow pain of ≥ 6 weeks duration

• Diagnosed clinically as lateral elbow tendinopathy

• Activity-related lateral elbow pain

• Tenderness of the lateral epicondyle

• Pain with gripping and/or resisted wrist extension with the elbow extended

• Pain with passive wrist flexion and finger with the elbow extended

• Internet access to complete electronic surveys

Exclusion Criteria:

• Prior surgery of the affected elbow

• Prior injection of the affected lateral epicondyle or extensor tendons

• Prior extracorporeal shockwave therapy to the affected elbow

• Suspicion for radial tunnel syndrome (tenderness distal to the lateral epicondyle in the area of the supinator muscle dorsally, pain with resisted supination with the elbow extended, and/or weakness of the extensor digitorum communis)

• Separate upper extremity injury or condition that would interfere with full participation in the home exercise program

• Fluoroquinolone-associated tendinopathy

• Ligamentous laxity on exam

• Evidence of osteoarthritis or osteochondral lesion on radiographs

• Autoimmune condition

• Pregnant, intend to become pregnant, or breastfeeding

• Premenopausal women who are not using contraception

• Allergy to doxycycline or other tetracyclines

• Current esophagitis or peptic ulcer disease

• Current use of medication for which there is a drug interaction with doxycycline

• Who do not speak English