Doxycycline in the Treatment of Aggressive Periodontitis

• Status: Completed
• Trial end date: 2014-12-08
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the study was to compare the clinical effects of systemic use of doxycycline to amoxicillin plus metronidazole as adjunctive treatment in nonsurgical debridement of aggressive periodontitis (AgP). Twenty four patients with aggressive periodontitis were enrolled in this clinical study. They all received oral hygiene instruction and full-mouth nonsurgical debridement using manual instruments. The test group received as adjunctive antibiotic treatment 200 mg of doxycycline the first day followed by 100 mg per day during 14 days. The control group received 500 of amoxicillin and 250 of metronidazole, three times a day for 7 days.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Mohammed V Souissi University
• Treatments: Amoxicillin; Doxycycline; Metronidazole

Criteria

Inclusion Criteria:

• subjects in good general health,

• presence of at least 20 teeth,

• no periodontal treatment performed during the previous 12 months,

• absence of antibiotic intake during six months before the study,

• and no known allergies to antibiotics used in the study

Exclusion Criteria:

• pregnancy,

• lactation,

• and smoking.