Drug-Drug Interaction Study Between Colchicine and Cyclosporine
Status:
Completed
Trial end date:
2008-09-01
Target enrollment:
Participant gender:
Summary
Colchicine is a substrate for both cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp).
Cyclosporine is a potent inhibitor of both CYP3A4 and P-gp. This study will evaluate the
effect of single-dose cyclosporine on the pharmacokinetic profile of a single 0.6 mg dose of
colchicine. A secondary objective is to evaluate the safety and tolerability of this regimen
in healthy volunteers. All study subjects will be monitored for adverse events throughout the
study period