Drug-Drug Interaction Study With Aricept® (Donepezil)

• Status: Completed
• Trial end date: 2010-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to find out if the plasma concentration of donepezil is changed when BMS-708163 is administered at the same time

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Bristol-Myers Squibb
• Treatments: Donepezil

Criteria

Inclusion Criteria:

• Healthy men and postmenopausal women

Exclusion Criteria:

• Medical History and Concurrent Diseases

• Gastrointestinal disease

• Gastrointestinal bleeding disorders

• History of peptic ulcer disease

• History of cholecystectomy

• History of seizure disorder

• History of asthma

• History of Chronic Obstructive Pulmonary Disease

• History of cardiac conduction abnormalities, including but not limited to "sick sinus syndrome" and those with unexplained syncopal episodes

• Inability to tolerate oral medication

• Inability to be venipunctured and/or tolerate venous access