Drug-Drug Interaction Study of Colchicine and Clarithromycin
Status:
Completed
Trial end date:
2008-01-01
Target enrollment:
Participant gender:
Summary
Clarithromycin is a potent inhibitor of the activity of cytochrome P450 (CYP) 3A4 and
P-glycoprotein (P-gp). CYP 3A4 plays a role in the metabolism of colchicine and P-gp is
responsible for the efflux of colchicine across membranes. This study will evaluate the
effect of clarithromycin-related inhibition of CYP 3A4 and P-gp on the pharmacokinetics of
colchicine. It will also evaluate the safety and tolerability of concurrent administration of
clarithromycin and a single dose of colchicine.