Drug-Drug Interaction Study of Entinostat and Exemestane in Postmenopausal Women With ER+ Breast Cancer
Status:
Unknown status
Trial end date:
2018-12-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine the effect of exemestane on the pharmacokinetics
(PK) of entinostat and to determine the effect of entinostat on the PK of exemestane in
patients with locally recurrent or metastatic estrogen receptor positive (ER+) breast cancer.
Additionally, this study will evaluate the safety and tolerability of entinostat in
combination with exemestane, and assess the effectiveness of entinostat in combination with
exemestane in terms of best overall response and overall survival.