Drug-Drug Interaction Study of "CG100650" in Healthy Volunteers

• Status: Unknown status
• Trial end date: 2019-12-30
• Target enrollment: 0
• Participant gender: All

Summary

This is a randomized, open-label, multiple-dose, parallel, Phase 1 study to compare the pharmacokinetics and to evaluate Drug-Drug Interaction of "CG100650" in healthy volunteers.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: CrystalGenomics, Inc.
• Treatments: Tramadol

Criteria

Inclusion Criteria:

1. Male or female aged ≥ 19 years and ≤ 50 years

2. Without inborn or chronic disease and no symptoms in physical examination

3. BMI(Body Mass Index) result ≥ 18kg/m 2 and ≤ 30kg/m2

4. Adequate clinical laboratory test results as evidenced by Hematology, Hemostasis, Biochemistry, Urinalysis, Serology and so on

5. After taking a rest in sitting position for 5 minutes, subjects who have blood pressure (90 mmHg ≤ Systolic BP ≤ 139 mmHg, and 60 mmHg ≤ Diastolic BP ≤ 89 mmHg)

6. Subject who understand the objective, method of the study and the characteristics of investigational drug and expected adverse events and provide written informed consent prior to study participation

7. Negative pregnancy test(hCG) and agree to contraception during the trial

Exclusion Criteria:

1. History of hypersensitivity to investigational products

2. History of hypersensitivity or allergic reaction to sulfonamide.

3. Patients with a history of asthma, acute rhinitis, nonspecific polyps, angioedema, urticaria or allergic reactions to aspirin or other nonsteroidal anti- inflammatory analgesics (including COX-2 inhibitors)

4. Genetically galactose intolerance, lactose intolerance or Glucose-Galactose Malabsorption

5. Uncontrolled hypertension (over the Systolic BP 140 mm Hg or Diastolic BP 90 mmHG)

6. Edema or Fluid retention

7. AST / ALT > 1.5 times the normal range including additional and Screening blood tests before randomization.

8. MDRD < 60mL / min / 1.73m2 including additional and Screening blood tests before randomization.

9. Any of the ECG result as below at Screening visit:

• PR interval > 210 msec

• QRS complex > 120 msec

• QTcF > 450 msec

10. Patient with an active peptic ulcer or gastrointestinal bleeding

11. Patient with inflammatory intestinal disease such as Crohn's disease or ulcerative colitis

12. Patient with Congestive Heart Failure (NYHA II - IV)

13. Established ischemic heart disease patients, peripheral arterial diseases, and/or brain vascular diseases patient

14. patient with gastrointestinal related disease or gastrotomy history (except appendicitis or hernia surgery) that may affect the absorption of the investigational drug.

15. Patient participated in any other clinical trials or Bio-equivalence studies within 90 days prior to the first administration of the investigational drug.

16. Patient donated whole blood within 60 days, donated blood component within 14 days, or received blood transfusion within 30 days prior to the first administration of the investigational drug.

17. Taken medications like barbital or herbal medicines within 30 days or taken Over The Counter medicines within 7 days prior to the first administration of the investigational drug that may affect the clinical trial

18. Over smokers (tobacco > 20 cigarettes/ days) within 30 days prior to Screening visit or patient cannot quit smoking during and until the end of the clinical trial after signed the Informed Consent Form to participate the clinical trial.

19. Excessive Alcohol consumer 30 days prior to Screening visit (more than 24 glasses /week (1 glass =wine 150 ml, beer 360 ml, spirits 45 ml)) or cannot quit drinking alcohol during and until the end of the clinical trial after signed the Informed Consent Form to participate the clinical trial.

20. Excessive caffeine consumer (> 5 drinks/ day)

21. Patient cannot accept medically acceptable contraception during and until the clinical trial.

22. Any other reasons or situations that the investigator decides the patient is not eligible to participate the clinical trial.