Drug Interaction Study of Azithromycin and Theophylline

• Status: Completed
• Trial end date: 2014-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Macrolides are potent inhibitors of cytochrome P450 isoenzyme 3A4（CYP3A4）and thus interfere with the pharmacokinetics of many other drugs that are metabolised by this enzyme like theophylline.The aim of this study is to determine whether azithromycin can effect theophylline metabolism in patients.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Zhujiang Hospital
• Treatments: Azithromycin; Theophylline

Criteria

Inclusion Criteria:

• patients with COPD or asthma，aged 18-75 years;

• regularly visiting our hospital;

• meeting the indications for azithromycin and theophylline simultaneously;

Exclusion Criteria:

• patients with renal or hepatic dysfunction;

• patients with congestive heart failure;

• patients with hypothyroidism or hyperthyroidism;

• patients taking drugs likely to affect the theophylline metabolism in the preceding week;

• patients with severe chronic obstructive pulmonary disease,asthma or respiratory infection;