Drug Interactions Between Morphine and Orally or IV Administered Acetaminophen
Status:
Completed
Trial end date:
2016-03-01
Target enrollment:
Participant gender:
Summary
Morphine is the opioid used to treat pain after surgery. Acetaminophen (called APAP) can
reduce the amount of opioids needed for this.
The problem is that morphine slows down digestion. That can delay pain relief from APAP
pills. It can even change what the body does to the drug [pharmacokinetics (PK)].
Some doctors have started using intravenous (IV) APAP with morphine, instead of the pills.
This study will measure the PK of APAP pills and IV when used with morphine in healthy
volunteers.
IV APAP will likely be more effective and cause fewer side effects when used with morphine to
treat pain after surgery.