Drug Nephrotoxicity Amelioration by N-acetylcysteine
Status:
Recruiting
Trial end date:
2024-05-30
Target enrollment:
Participant gender:
Summary
When treating individuals with febrile neutropenia, amphotericin B (AmB-d) is one of the most
effective treatments against often fatal systemic fungal infections.Nephrotoxicity from
amphotericin B can develop with an incidence of up to 80.This emphasizes the value of
nephroprotectant agent use.Because of N-acetylcysteine's antioxidant, antiapoptotic,
vasodilator properties and its therapeutic effects on contrast nephropathy. Acetylcysteine's
impact on amphotericin B-induced nephrotoxicity in cancer patients is assessed.