Drug-drug Interactions Between Remdesivir and Commonly Used Antiretroviral Therapy
Status:
Completed
Trial end date:
2021-07-16
Target enrollment:
Participant gender:
Summary
Ebola and HIV are found predominately in the same regions of the world and countries in
sub-Saharan Africa are most affected by both diseases. For Ebola, no approved therapies
exist. However, new investigational drugs are being evaluated to understand if they are
effective against the Ebola virus. Remdesivir is an anti-Ebola investigational drug for the
treatment of Ebola. Little is known about how the blood levels of remdesivir relate to how
effective it is in patients with HIV taking antiretroviral therapy. This study will explore
how commonly utilized ART (tenofovir/lamivudine and atazanavir/ritonavir) affect the drug
levels of remdesivir.
Phase:
Phase 2
Details
Lead Sponsor:
Makerere University
Collaborators:
EDCTP European and Developing Countries Clinical Trials Partnership (EDCTP) University of Liverpool University of Turin, Italy