Drug-induced Xerostomia. Evaluation of Malic Acid 1%, Salivary Mucins and Buffering Capacity
Status:
Completed
Trial end date:
2014-01-01
Target enrollment:
Participant gender:
Summary
The aim of our study was to evaluate the clinical efficacy of a topical sialogogue spray
containing 1% malic acid on patients affected by xerostomia caused by drugs.
This research took the form of a double-blind, randomized clinical trial at Faculty of
Dentistry of University of Granada (Spain). Participants with antidepressant-induced and
antihypertensive-induce xerostomia were divided into two groups: for the first 'intervention
group' a topical sialogogue spray (1% malic acid) was applied, while for the second 'control
group', a placebo spray was applied; for both groups the sprays were applied on demand during
two weeks. The Dry Mouth Questionnaire (DMQ) was used to evaluate xerostomia levels before
and after product/placebo application. Unstimulated and stimulated salivary flows rates,
before and after application, were measured.