DuoStim in Cases of PGT: Comparison of Embryo Quantity and Embryonic Quality Using MitoScore
Status:
Completed
Trial end date:
2020-06-01
Target enrollment:
Participant gender:
Summary
Since preimplantation genetic testing (PGT) is being more frequently requested from patients
as women pursue infertility treatments at an advanced age with a poorer prognosis, sometimes
physicians are compelled to perform several stimulation cycles to obtain more eggs and,
consequently, a greater number of biopsied embryos. Hence, the idea of carrying out this
study arises as an attempt to optimize each menstrual cycle to the maximum.
It is believed that the double stimulation (DuoStim) protocol could be an alternative for
this group of patients, allowing to obtain a larger number of oocytes in a shorter period,
thus, increasing the number of biopsied embryos and possibly decreasing the interval to
achieve a successful pregnancy.
The investigators aim to evaluate the potential usefulness of the DuoStim protocol for
patients desiring to obtain oocytes as soon as possible. Using PGT, the investigators will
compare the rate of euploid embryos per cycle in patients undergoing DuoStim protocol versus
patients undergoing two conventional controlled ovarian hyperstimulation in consecutive
cycles. Patients will include women with advanced age and poor response.
This is a unicentric, prospective, randomized, non-blind, parallel-group controlled phase IV
clinical study. The investigators hypothesize that the rate of euploid embryos per cycle is
similar in the DuoStim group compared to the group undergoing two conventional controlled
ovarian hyperstimulation in consecutive cycles.
Furthermore the investigators will evaluate if there are differences regarding the number of
total oocytes obtained, the number of mature oocytes, the number of biopsied blastocysts and
the MitoScore index of the available euploid embryos.