Duodenal Levodopa Infusion, Quality of Life and Autonomic Nervous System in Parkinson's Disease

• Status: Completed
• Trial end date: 2011-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the study is to assess the effect of continuous levodopa infusion on autonomic nervous system in patients with Parkinson's Disease (PD), blood pressure regulation and sweating. The investigators' hypothesis is that levodopa infusion may alleviate hyperhidrosis and orthostatic hypotension.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Helsinki University; University of Helsinki
• Collaborator: Solvay Pharmaceuticals
• Treatments: Levodopa

Criteria

Inclusion Criteria:

• Diagnosis of idiopathic Parkinson's disease: diagnosis made at least five years earlier

• Positive response to levodopa

• Motor fluctuations that cannot be adequately controlled with oral medication

• No signs or symptoms of cerebellar dysfunction or vascular parkinsonism

Exclusion Criteria:

• Severe cognitive symptoms

• Glaucoma

• Severe arrythmias

• Severe asthma or COPD

• Heart, liver or kidney failure

• No significant vascular lesions in brain MRI imaging.