Overview

Durability of Combination Therapy With Exenatide/Pioglitazone/Metformin vs. Conventional Therapy in New Onset T2DM

Status:
Active, not recruiting
Trial end date:
2024-12-01
Target enrollment:
0
Participant gender:
All
Summary
Type 2 diabetes is a systemic metabolic disease with significant morbidity and mortality due to damaging blood vessels. Increased blood sugar level is a hallmark of diabetes and is an contributes to the development of many of its complications. Multiple defects, e.g. impaired insulin secretion and impaired insulin action, contribute to the development of the disease. The aim of this study is to test the efficacy and durability of combination of drugs which correct the defects that lead to the development of diabetes on achieving adequate and durable control of blood sugar levels. Achieving adequate and durable control of blood sugar will prevent many of diabetes complications.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
The University of Texas Health Science Center at San Antonio
Collaborators:
American Diabetes Association
Amylin Pharmaceuticals, LLC.
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Treatments:
Exenatide
Glyburide
Insulin Glargine
Metformin
Pioglitazone
Criteria
Inclusion Criteria:

- subjects with type 2 diabetes diagnosed during the past 2 years,

- above 18 years of age,

- drug naive, or have been on metformin less than 3 months

Exclusion Criteria:

- subjects with type 1 diabetes or GAD positive subjects or subjects with long standing
diabetes (>2 years) or subjects who are not drug naive or have been on metformin more
than 3 months.