EBV CTLs Expressing CD30 Chimeric Receptors For CD 30+ Lymphoma
Status:
Active, not recruiting
Trial end date:
2033-10-01
Target enrollment:
Participant gender:
Summary
The body has different ways of fighting infection and disease. No single way seems perfect
for fighting cancer. This research study combines two different ways of fighting disease:
antibodies and T cells. Antibodies are proteins the protect the body from diseases caused by
germs or toxic substances. They work by binding those germs or substances, which stops them
from growing and causing bad effects. T cells, also called T lymphocytes, are special
infection-fighting blood cells that can kill other cells, including tumor cells or cells that
are infected with germs. Both antibodies and T cells have been used to treat patients with
cancers: they both have been shown promise, but have not been strong enough to cure most
patients. This study combines the two methods.
We have found from previous research that we can put a new gene into T cells that will make
them recognize cancer cells and kill them. We now want to see if we can attach a new gene to
T cells that will help them do a better job at recognizing and killing lymphoma cells.
The new gene we will put in T cells makes an antibody called anti-CD30. The antibody alone
has not been strong enough to cure most patients. For this study, the anti-CD30 antibody has
been changed so that instead of floating free in the blood it is now joined to the T cells.
When an antibody is joined to a T cell in this way it is called a chimeric receptor. These
chimeric receptor-T cells seem to kill some of the tumor, but they don't last very long and
so their chances of fighting the cancer are unknown.
We have found that T cells that are also trained to recognize the EBV virus (that causes
infectious mononucleosis) can stay in the blood stream for many years. These are called EBV
specific Cytotoxic T Lymphocytes.
By joining the anti-CD30 antibody to the EBV CTLs, we believe that we will also be able to
make a cell that can last a long time in the body and recognize and kill lymphoma cells. We
call the final cells CD30 chimeric receptor EBV CTLs. T
We hope that these new cells may be able to work longer and target and kill lymphoma cells.
However, we do not know that yet.
Phase:
Phase 1
Details
Lead Sponsor:
Baylor College of Medicine
Collaborators:
Center for Cell and Gene Therapy, Baylor College of Medicine Texas Children's Hospital The Methodist Hospital Research Institute The Methodist Hospital System