EBV-Specific Anti-PD1 TCR-T Cells in the Treatment of EBV-Positive NHSCC

• Status: Recruiting
• Trial end date: 2022-02-28
• Target enrollment: 0
• Participant gender: All

Summary

Epstein-Barr virus (EBV) infections is known to be a high-risk factor to induce nasopharyngeal cancers. To date, EBV-related head and neck squamous cell carcinoma (HNSCC) is still a major concern in east Asia, especially in China. Concurrent therapies for HNSCC have limited response rate and high chance of relapse. However, EBV-induced cancers provided an ideal target for T cell-based immunotherapy due to the non-self origins. Engineered T cells bearing a TCR (TCR-T) that can specifically recognize the presented EBV antigen become a viable approach to treat this type of cancer. Though engineered T therapies have been well-recognized in hematological cancers, solid cancer treatment has been a major hurdle due to the immune-suppressive tumor microenvironment. One key mechanism of tumor-elicited suppression is the PDL1-PD1 interaction which induces T cell exhaustion. Therefore, TCR-T cells armed with a PD1 antagonist could further enhance the efficacy of TCR-T in solid cancers.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Xinqiao Hospital of Chongqing
• Collaborator: TCRCure Biopharma Ltd

Criteria

Inclusion Criteria:

• Expected to live longer than 12 weeks

• PS 0-2

• Pathology confirmed as EBV positive HNSCC, either metastatic or recurrent disease

• Creatinine <2.5mg/dl

• ALT/AST is lower than three times ULN.

• No contraindications of leukocyte collection

• Before entering the trial, women must adopt a reliable method of contraception until 30 days after infusion.

• Understand this trial and have signed an informed consent

Exclusion Criteria:

• Patients with symptomatic brain metastasis

• With other uncontrolled malignant tumors.

• Hepatitis B or Hepatitis C activity period, HIV infected patients

• Any other uncontrolled disease that interferes with the trial

• Patients with severe heart and cerebrovascular diseases such as coronary heart disease, angina pectoris, myocardial infarction, arrhythmia, cerebral thrombosis and cerebral hemorrhage

• Untreated hypertension or hypertensive patients

• A person with a history of mental illness that is difficult to control

• Researchers do not consider it appropriate to participate in this trial

• Patients who have been using immunosuppressive agents for a long time after organ transplants, except for recent or current inhaled corticosteroids

• Subjects who have been pregnant or nursing, or who plan for pregnancy within 2 months of treatment or after the end of treatment

• An illness affects a person who signs a written consent or complies with a study procedure, or who is unwilling or unable to comply with the research requirements