ECT With Ketamine Anesthesia vs High Intensity Ketamine With ECT Rescue for Treatment-Resistant Depression
Status:
Recruiting
Trial end date:
2022-12-30
Target enrollment:
Participant gender:
Summary
To determine if an high intensity ketamine with ECT rescue (HIKER) approach for treatment
resistant depression will: 1) reduce patient suffering by hastening disease remission, 2)
have fewer side effects, 3) reduce the need for ECT, and 4) be preferred by most patients.
Half of participants will be randomized to the HIKER arm and receive high intensity ketamine
treatment for eight consecutive days, and the other half will be assigned to the ECT with
ketamine anesthesia (EAST) arm and receive 8 ECT treatments (2-3 treatment/week)