ED Treatment of Suicidal Patients With Ketamine Infusion

• Status: Withdrawn
• Trial end date: 2019-06-30
• Target enrollment: 0
• Participant gender: All

Summary

This study aims to determine if a single intravenous (IV) dose of ketamine given in the emergency department (ED) can provide a long term reduction in suicidal ideation, lower time to ED discharge, and increase discharge to home or voluntary treatment facilities all while being safe.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of California, Davis
• Treatments: Ketamine

Criteria

Inclusion Criteria:

• Age ≥ 18 years

• Chief complaint of suicidal thoughts with a MADRS-SI score > 3

• Major depressive episode with MADRS > 19 (moderate to severe)

Exclusion Criteria:

• Pregnancy

• Psychosis

• Acute intoxication with alcohol or illicit drugs

• Acute withdrawal from alcohol or illicit drugs

• Adults otherwise unable to consent

• Concurrent, active medical illness requiring medical hospitalization

• Inability to follow-up including no permanent address or valid telephone number

• Patients unable to attend outpatient follow-up (no medical insurance, refusal to follow-up, no established care provider)

• Specific contraindication to the use of ketamine (concern for increased intracranial or intraocular pressure, known allergy to ketamine)

• Greater than 12 hours from time of ED presentation

• Prisoners