ED50 Determination of Hydroxyethylstarch for Treatment of Hypotension During Cesarean Section Under Spinal Anesthesia

• Status: Unknown status
• Trial end date: 2013-06-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this trial is to determine the effective volume of hydroxyethylstarch 130/0.4 which would prevent the occurence of maternal hypotension in 50% of healthy pregnant women undergoing a cesarean section under spinal anesthesia.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Maisonneuve-Rosemont Hospital
• Collaborator: Université de Montréal
• Treatments: Anesthetics; Hydroxyethyl Starch Derivatives

Criteria

Inclusion Criteria:

• Healthy pregnant women (ASA I or II)

• Normal pregnancy

• Term gestation (37 weeks and above)

• Elective cesarean section

• Spinal anesthesia

Exclusion Criteria:

• Cardiopathies

• Hypertensive disease/ pre-eclampsia / eclampsia

• Any contraindication to neuraxial anesthesia

• Patient refusal

• Body mass index > 30 at first antenatal visit and > 32 at cesarean section

• Twin pregnancy

• Known allergies to HES

• Emergency cesarean section