EEG Characteristics in ECT

• Status: Unknown status
• Trial end date: 2020-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators will be examining slow-wave characteristics in depressed patients receiving electroconvulsive therapy (ECT) using direct current electroencephalogram (dcEEG) by anesthesia induction agent.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of New Mexico
• Collaborator: University of New Mexico Clinical & Translational Science Center
• Treatments: Ketamine; Methohexital

Criteria

Inclusion Criteria:

• Structured Clinical Interview for DSM-5 will confirm diagnosis of MDD or BPD-depressed (with or without psychotic features

• The clinical indications for ECT including treatment resistance or a need for a rapid and definitive response;

• Hamilton Depression Rating Scale 24-item (HDRS-24) > 21; and

• Age range between 18 and 65 years of age.

Exclusion Criteria:

• Defined neurological or neurodegenerative disorder (e.g., history of head injury with loss of consciousness > 5 minutes, epilepsy, Alzheimer's disease);

• Other psychiatric conditions (e.g., schizophrenia, schizoaffective disorder, bipolar disorder)

• Current drug or alcohol use disorder, except for nicotine and marijuana

• Adults unable to consent, pregnant women, prisoner

• Non-English speakers

• Patients that cannot tolerate Methohexital and Ketamine.