EEG-fMRI Experiments During Anesthesia Induction With Propofol

• Status: Recruiting
• Trial end date: 2026-09-10
• Target enrollment: 0
• Participant gender: All

Summary

This observational study aims to investigate healthy cortical and subcortical neural processes involved in generating intrinsic alpha oscillations during induction of general anesthesia with propofol. To do this, the investigators have designed a simultaneous electroencephalogram (EEG)- MRI (functional MRI and Spectroscopy) experiment with a visual stimulation paradigm that addresses the subject's specific intrinsic alpha rhythm during anesthesia and wakefulness. The main question it aims to answer is: could the investigators address the alpha oscillation system of the healthy brain with external stimulation during anesthesia? This experiment could lead to a better understanding of the mechanisms underlying the generation of alpha oscillations. It could open new doors to diagnostic and treatment options for diseases where alpha oscillations, such as post-operative delirium, seem to be affected.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Technical University of Munich
• Treatments: Propofol

Criteria

Inclusion Criteria:

• Female and male healthy individuals (ASA I: assessed according to the American Society of Anesthesiologists Physical Status Classification System a non-acute or chronic disease), non-pregnant, non-smokers, non-drug-users, and presenting no or minimal alcohol use.

• Age: 18 to 35 years

• Capacity to give consent

• Written consent after detailed information.

Exclusion criteria:

• Individuals who do not meet all inclusion criteria

• Previous brain surgery

• History of epileptic seizures

• History of psychiatric or neurological disease

• Physical status other than American Society of Anesthesiologists physical status I, e.g., presence of severe internal or systemic disease

• Chronic intake of medication or drugs (Alcohol, Marihuana, Cocaine, Opioids, Benzodiazepine, etc.)

• Impaired hearing or presence of deafness

• Absence of fluency in the German language

• Known disposition to malignant hyperthermia

• Previous diagnosis of hepatic porphyria

• Body mass index greater than 30 kg/m2

• Gastrointestinal disorders with a disposition for gastroesophageal regurgitation

• Known or suspected difficult airway

• Known hypersensitivity to propofol or any propofol injectable emulsion components (i.e., eggs, eggs products, soybeans, or soy products)

• Atopy/severe allergies/asthma

• Cardiological abnormalities: torsades de pointes, prolonged QT interval, QT changes present since birth.

• Contraindications to MRI (e.g., pacemakers, artificial heart valves, cardioseal, aneurysm clips, implanted magnetic metal parts (screws, plates from surgery), cochlear implants, metal splitters/grenade splinters, acupuncture needle, insulin pump, piercings that cannot be removed, etc)

• Pregnancy

• Subjects with claustrophobia