EFFECTIVENESS OF FOLIC ACID IN ACUTE WATERY DIARRHEA AMONG CHILDREN

• Status: Recruiting
• Trial end date: 2021-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Folic acid is a palatable and easily available drug with no serious adverse effects. L-methylfolate is its biologically activated form and is preferred because of its direct availability for certain metabolic processes. As there is no specific and safe drug available that may help in decreasing the duration of diarrhea, purging rate or consistency of stools; and having known the theoretical benefits of folic acid in this regard, it would be appropriate to assess the effectiveness of L-methylfolate among children with diarrhea.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: King Edward Medical University
• Treatments: Calcium

Criteria

Inclusion Criteria:

• Children aged 2months- 5 years

• Both genders

• Acute watery diarrhea as per operational definition

• Diarrhea of less than 7-day duration

Exclusion Criteria:

• Severely malnourished children <3 SD

• Bloody diarrhea

• Prolonged (7-14 days duration), persistent (>14 days duration) or chronic diarrhea (>4weeks duration)

• Those who received folic acid within the last 14 days

• Hospital-acquired diarrhea (diarrhea occurring after 48hrs of stay in hospital)

• Antibiotic-associated diarrhea.

• Presence of other co morbid conditions like pneumonia, sepsis, meningitis, etc.