EFFECTS OF MOXIFLOXACIN AND GEMIFLOXACIN ON BLOOD GLUCOSE LEVEL OF EUGLYCEMICS:A PRE-CLINICAL AND CLINICAL STUDY
Status:
Completed
Trial end date:
2021-04-01
Target enrollment:
Participant gender:
Summary
EFFECTS OF MOXIFLOXACIN AND GEMIFLOXACIN ON BLOOD GLUCOSE LEVEL OF EUGLYCEMICS:A PRE-CLINICAL
AND CLINICAL STUDY.
Our aim and objectives are to:
1. Identify the possible mechanism of secretion of insulin via ATP-sensitive K+ channels
through power lab in comparison to a standard.
2. Determine the blood glucose, insulin and C-Peptide levels in animal model plus
euglycemics using Moxifloxacin and Gemifloxacin in their recommended daily doses per
oral route and to check the histomorphological features changes of the pancreatic tissue
of rabbits (in vivo).
3. Translate the results of animal model and healthy volunteers for possible effects on
release of insulin, peptide and subsequent shift in blood glucose level of healthy
volunteer (target population).
In the above entitled studies we are going to determine the effects of the above two 4th
generation fluoroquinolones drugs on the blood glucose levels of euglycemics healthy
volunteers.The drug will be gave as per approved standard adult dose.The drug is FDA approved
and marketed drug.No risk is to the patient only 3-5 ml of the blood will be taken at
baseline and after the drug completion at steady state concentration.
Phase:
Phase 1
Details
Lead Sponsor:
Shaheed Benazir Bhutto University Sheringal Dir Upper