EIMD Mechanisms Causing Force Loss

• Status: Terminated
• Trial end date: 2015-05-01
• Target enrollment: 0
• Participant gender: All

Summary

We have hypothesized: 1) Caffeine will increase maximal voluntary strength compared to placebo in undamaged muscle. 2) Caffeine will increase muscle activation compared to placebo in undamaged muscle. 3) Caffeine will enhance spinal excitability (indicated by an enhanced H-reflex) compared to placebo in undamaged muscle. 4) Caffeine will raise the pressure-pain threshold (indicating decreased pain sensitivity) in the calf muscle compared to placebo in undamaged muscle. 5) Caffeine will reduce the amount of low-frequency fatigue, indicated by an enhanced 20-100 hertz strength ratio, compared to placebo in undamaged muscle. 6) Caffeine will increase maximal voluntary strength compared to placebo in damaged muscle. 7) Caffeine will increase muscle activation compared to placebo in damaged muscle. 8) Caffeine will enhance spinal excitability (indicated by an enhanced H-reflex) compared to placebo in damaged muscle. 9) Caffeine will raise the pressure-pain threshold (indicating decreased pain sensitivity) in the calf muscle compared to placebo in damaged muscle. 10) Caffeine will reduce the amount of low-frequency fatigue, indicated by an enhanced 20-100 hertz strength ratio, compared to placebo in damaged muscle.

The proposed research will determine the effects of a 5mg/kg body weight dose of caffeine on muscular strength, activation, H-reflex function, and excitation-contraction coupling before and after exercise-induced muscle damage. The long term objectives are to gain a better understanding of caffeine and its affects following exercise-induced muscle damage allowing us to understand how caffeine is mechanistically interacting with functions of the body.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Oklahoma
• Treatments: Caffeine

Criteria

Inclusion Criteria:

• age range of 18-35 years of age

• males and females who do not have a history of orthopedic injuries of the hip knee, and/or leg

• Participants must be engaged in some form of physical activity on at least 3 days each week

Exclusion Criteria:

• An answer of "yes" to any of the seven questions on the physical activity readiness questionnaire (PAR-Q)

• Average daily consumption of more than 40mg of caffeine per day as determined by the 2 week caffeine recall questionnaire

• Use of any type of prescription psychiatric or prescription or over-the-counter pain medication

• An answer of "yes" to questions 1,2,8, and 15-22 on the rhabdomyolysis screening questionnaire

• An answer of "yes" on questions 3,4,6,7,8, 11,12, and 13 if the follow up information indicates any type of medication, drug, supplement, illness, and/or dietary need that could affect pain sensitivity or the risk of dehydration. Determinations will be made on a participant-by-participant basis depending on the answers provided

• An answer of "yes" on question 24 indicating a previous adverse reaction to caffeine consumption

• Resting systolic blood pressure >140 mmHg and/or resting diastolic blood pressure >90 mmHg

• Pregnancy or suspicion of pregnancy.