EPO for Postop Delirium in Elderly Patients

• Status: Completed
• Trial end date: 2019-08-28
• Target enrollment: 0
• Participant gender: All

Summary

Postoperative delirium is a common complication after surgery. The underlying pathophysiology of this complication is unclear, however neuroinflammation and oxidative stress secondary to surgery had shown to be the cause of postoperative cognitive dysfunction and delirium. Erythropoietin represents non-erythropoietic effects of anti-inflammatory properties. The aims of this study were to determine the role of erythropoietin toward the development of postoperative delirium, in terms of changes in inflammatory reaction by affecting the innate immunity in elderly patients undergoing total joint arthroplasty surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yonsei University
• Treatments: Epoetin Alfa

Criteria

Inclusion Criteria:

• Age 65 years and older

• Patients scheduled for elective total knee arthroplasty, total hip arthroplasty

Exclusion Criteria:

• Unable to communicate

• Cognitive impairment

• Unable to pre-screen delirium due to underlying central nervous system disease

• History of hypersensitivity related to erythropoietin and other anesthesia-related drugs

• History of myocardial infarction, pulmonary infarction, cerebral infarction, ischemic vascular disease, epilpesy, chronic liver disease, chronic kidney disease

• Uncontrolled high blood pressure

• Within one month of starting anti-hypertensive medication