EUS-guided Combined Therapy Versus Beta Blocker Therapy in Primary Prophylaxis o GOV II and IGV I

• Status: Unknown status
• Trial end date: 2020-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The EUS-guided combined therapy of coilingand 2-octyl-cyanoacrylate in patients with gastric varices reduced rebleeding and need for reintervention in comparison to EUS-guided coiling alone.The purpose of this study is to determine the efficacy of the primary prophylaxis of GOV II and IGV I with the EUS combined therapy versus beta blocker therapy in patients GOV II and IGV that have never bleed.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Instituto Ecuatoriano de Enfermedades Digestivas
• Treatments: Adrenergic beta-Antagonists; Propranolol

Criteria

Inclusion Criteria:

• Above 18 years old

• Writeen informed consent provided.

• Proven GV (GOV II or IGV I) on esophagogastroduodenoscopy and EUS.

• Gastric varices with high-risk of bleeding (large diameter, high MELD score, presence of portal hypertensive gastropathy)

• Patient preference for EUS-guided therapy.

Exclusion Criteria:

• Under 18 years old.

• Refuse to sign written informed consent.

• Pregnancy or nursing.

• Previous treatment of gastric varices.

• Non-cirrhotic portal hypertension

• Concurrent hepato-renal syndrome and/or multi-organ failure.

• Proven malignancy including hepatocellular carcinoma

• Platelet count less than 50,000/ml or International Normalized Rate (INR) >2.

• Severe ascites that increases the distance between gastric or duodenal and gallbladder walls.

• Esophageal stricture.

• Uncontrolled coagulopathy.