EVALUATION OF THE RELATIONSHIP BETWEEN EFFERVESCENT PARACETAMOL AND BLOOD PRESSURE. CLINICAL TRIAL.
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Paracetamol's solubility is achieved by adding to the excipient sodium salts, either as
bicarbonate, carbonate or citrate. As the relationship between salt and hypertension is well
known, due to the sodium content it has raised a hypothesis that may interfere with the
control of that risk factor.
Therefore, the objective of this study is to evaluate the effect on blood pressure of
effervescent paracetamol compared to non-effervescent, in hypertensive patients.
This is a multicenter, randomized, controlled, crossover, open, phase IV clinical trial,
which compares the effect of two different formulations of paracetamol (effervescent or
non-effervescent tablets) in the blood pressure of hypertensive patients after 3 weeks
treatment (coded EUDRACT 2010-023485-53). The washing time between the two periods is
approximately 1 week (minimum 3 days)