Early Antiplatelet Therapy After Hemorrhagic Infarction in Acute Ischemic Stroke Treated With Intravenous Thrombolysis (HITs)

• Status: Recruiting
• Trial end date: 2023-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Previous study showed that the proportions of hemorrhagic Infarction after intravenous thrombolysis were 24.2% and 32.5% in the control group and the alteplase group, and most of them were asymptomatic. Hemorrhagic Infarction was a part of the natural progression after acute ischemic stroke. Previous study have shown no significant relationship between hemorrhagic Infarction and poor outcome in acute ischemic stroke (AIS) patients. In this study, a randomized controlled trial will be conducted to explore the efficacy and safety of early antiplatelet therapy after hemorrhagic infarction in acute ischemic stroke treated with intravenous thrombolysis.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
• Collaborators: First Affiliated Hospital of Jiaxing University; Huizhou Municipal Central Hospital; Jinhua Central Hospital; Lishui Country People's Hospital; Ningbo Medical Center Lihuili Hospital; Ningbo No.2 Hospital; Shaoxing People's Hospital; Shenzhen Second People's Hospital; Taizhou Hospital; The Affiliated Hospital of Xuzhou Medical University; The Fourth Affiliated Hospital of Zhejiang University School of Medicine; The Second Affiliated Hospital of Jiaxing University; Wenzhou Central Hospital
• Treatments: Aspirin

Criteria

Inclusion Criteria:

1. Acute ischemic patients receiving intravenous thrombolysis within 4.5 hours upon stroke onset

2. Be confirmed as Hemorrhagic Infarction at 24 to 36 hours after intravenous thrombolysis by computerized tomography

3. The patient or family member signed an informed consent

Exclusion Criteria:

1. Early use of anticoagulant drugs within 1 week after intravenous thrombolysis;

2. Tirofiban was used after receiving endovascular treatment;

3. Intraoperative stent placement after receiving endovascular treatment;

4. Subarachnoid hemorrhage or ventricular hemorrhage;

5. There are contraindications for aspirin use;