Early Basal Insulin Administration in Adult Diabetic Ketoacidosis Management
Status:
Terminated
Trial end date:
2021-08-27
Target enrollment:
Participant gender:
Summary
The transition from IV Insulin Infusion (IVII) to Subcutaneous Long-acting insulin injections
in Diabetic Ketoacidosis (DKA) management frequently results in rebound hyperglycemia,
particularly if there are high insulin requirements that can adversely affect the DKA
recovery, increase Length Of Stay (LOS), morbidity, and mortality. Investigators propose a
prospective, open-label, intervention, non-randomized, controlled study to test the
hypothesis that an insulin glargine dose of 0.4 Units/kg early administered (within four
hours) of IVII initiation in DKA management in adult would be effective and safe in
shortening the time to anion gap closure comparing to the standard practice.