Early Childhood Malaria Prevention With Maloprim in The Gambia

• Status: Completed
• Trial end date: 2001-09-01
• Target enrollment: 0
• Participant gender: All

Summary

A trial was conducted in the 1980s to compare two strategies for control of malaria in young children aged 3-59 months: treatment with chloroquine versus treatment combined with fortnightly chemoprophylaxis with Maloprim. The impact on mortality and morbidity was assessed at the time, and their cognitive abilities and educational outcomes were assess 14 years later in 2001. The hypothesis was that the chemoprophylaxis would reduce morbidity and mortality and would improve cognitive abilities and educational outcomes in the long term

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Imperial College London
• Collaborators: Government of the Gambia; London School of Hygiene and Tropical Medicine; Medical Research Council Unit, The Gambia; Partnership for Child Development; Wellcome Trust
• Treatments: Maloprim

Criteria

Inclusion Criteria:

• For original trial: Children aged 3-59 months present in participating villages

• For follow-up: Children who were in original trial for at least 1 year.

Exclusion Criteria:

• For original trial: None

• For follow-up: Children with mental or physical disabilities who were unable to do cognitive tests