Early Initiated Vasopressor Therapy in the Emergency Department
Status:
Recruiting
Trial end date:
2026-01-31
Target enrollment:
Participant gender:
Summary
The goal of this pragmatic, multi-center, superiority, randomized clinical trial is to
compare early treatment with peripheral (through a vein) infused noradrenaline (a natural
hormone that increases blood pressure) with fluid only therapy in patients with hypotensive
and shock in the Danish Emergency Departments (ED).
The main questions it aims to answer are:
If early initiated noradrenaline in non-bleeding hypotensive patients presenting in the ED
can
- Improve time to shock control.
- Reduce the need for ICU admittance.
- Decrease mortality.
Participants will be included by the clinical staff and treated urgently with either
noradrenaline or usual treatment during their Emergency Department stay.
After completion of the treatment in the Emergency Department, patient data will be extracted
from the bed-side measurements, electronic health records and national registers.
Patients will be contacted by the research staff 1 year after study inclusion to answer brief
questions about their daily physical function and ability to care for themselves.
Researchers will compare with patients receiving fluid therapy only, as this is the usual
standard of care in Danish Emergency Departments.