Early Levothyroxine Post Radioactive Iodine

• Status: Completed
• Trial end date: 2017-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The study will try to answer the question of whether early treatment with levothyroxine at 4 weeks after radioactive iodine for Graves'disease will prevent overt hypothyroidism (low thyroid hormone levels).

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mayo Clinic
• Treatments: Hormones; Iodine

Criteria

Inclusion criteria:

-all adult patients (ages 18-70 years) with Graves' Disease (GD) who will receive radioactive iodine (RAI) ablation of the thyroid gland for treatment of GD

Exclusion criteria:

• clinically manifest Graves' ophthalmopathy (GO)

• recent (<1 yr.) history of arrhythmias or any history of ventricular arrhythmias

• preexistent cardiomyopathy

• malnutrition

• psychiatric history that could get worse if patient remains persistently hyperthyroid

• unlikely to return for the planned follow-up visits

• unlikely to comply with the blood drawing schedule

• unlikely to complete the hypothyroid-Health Related Quality of Life (HDQL) and Thyroid Specific (TSQ) questionnaires