Early Metabolic Changes With Thiazide or Beta Blocker Therapy for Essential Hypertension

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Can the oral glucose tolerance test detect changes after 4 weeks treatment with thiazide diuretics or beta blockers or combination of the two?

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Cambridge
• Collaborator: Cambridge University Hospitals NHS Foundation Trust
• Treatments: Adrenergic beta-Antagonists; Sodium Chloride Symporter Inhibitors

Criteria

Inclusion Criteria:

• Volunteers will be aged 18-75 years.

• Hypertension- either

• untreated, BP 140-170/90-110

• treated for over 1 month with drugs other than beta blockers or diuretic and BP>140/85

• treated for over 1 month with drugs other than beta blockers or diuretic and BP<140/85 and patient willing to change medication for eight months.

Exclusion criteria:

• Any patient already taking thiazide diuretics or beta blockers in whom these drugs cannot be switched to alternative drugs with similar or better blood pressure control.

• Any patient who is intolerant of these medications will be excluded from the study.

• Patients with gout, asthma or any other contraindications to the study drugs will be excluded.

• Women of child bearing age not using contraception.

• Volunteers with heart failure, liver failure, renal failure, terminal illnesses (e.g. cancer)

• Volunteers not able to give informed consent

• Patients with diabetes