Early Use of Norepinephrine in Septic Shock Resuscitation

• Status: Completed
• Trial end date: 2017-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Current septic shock guideline recommends fluid resuscitation as the first treatment. Vasopressors, including norepinephrine is recommended to start after achieve adequate fluid therapy. This can cause a certain duration of systemic hypotension before vasopressor is commenced. Initiation of norepinephrine together with fluid therapy soon after diagnosis of septic shock may increase blood pressure quicker than start treatment with intravenous fluid alone. The rapid restoration of perfusion pressure may improve septic shock outcome.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mahidol University
• Collaborator: Siriraj Hospital
• Treatments: Norepinephrine

Criteria

Inclusion Criteria:

• Age > or = 18 years old

• Diagnosed severe sepsis or septic shock according to survival sepsis campaign 2013

• Mean arterial pressure < 65 mmHg

Exclusion Criteria:

• Pregnancy

• Severe underlying condition that unexpected to survive more than 48 hours

• Severe peripheral vascular disease

• Patient who required major surgery within 24 hours