Early Use of Norepinephrine in Septic Shock Resuscitation
Status:
Completed
Trial end date:
2017-08-01
Target enrollment:
Participant gender:
Summary
Current septic shock guideline recommends fluid resuscitation as the first treatment.
Vasopressors, including norepinephrine is recommended to start after achieve adequate fluid
therapy. This can cause a certain duration of systemic hypotension before vasopressor is
commenced. Initiation of norepinephrine together with fluid therapy soon after diagnosis of
septic shock may increase blood pressure quicker than start treatment with intravenous fluid
alone. The rapid restoration of perfusion pressure may improve septic shock outcome.