Early Versus Delayed Antiretroviral Therapy (ART) in the Treatment of Cryptococcal Meningitis in Africa
Status:
Completed
Trial end date:
2009-10-01
Target enrollment:
Participant gender:
Summary
Cryptococcal Meningitis continues to be one of the most devastating AIDS defining illness in
sub-Saharan Africa. Despite the availability of azoles such as fluconazole for treatment,
mortality remains high with some studies showing 100% mortality. The investigators designed a
study to determine if timing of the initiation of antiretroviral therapy (ART) in patients
with cryptococcal meningitis and HIV would improve survival. The investigators hypothesis was
that early initiation of ART result in improved mortality for patients with HIV and
cryptococcal meningitis.
Phase:
N/A
Details
Lead Sponsor:
University of Zimbabwe
Collaborator:
AIDS Care Research in Africa
Treatments:
Fluconazole Lamivudine Nevirapine Stavudine Stavudine, lamivudine, nevirapine drug combination