Early Versus Late Introduction of STN DBS in PD Patients With Motor Complications

• Status: Recruiting
• Trial end date: 0000-00-00
• Target enrollment: 200
• Participant gender: Both

Summary

Although deep brain stimulation of the subthalamic nucleus(STN DBS) has become the surgical treatment of choice for Parkinson's disease(PD), a consensus on the timing of surgery is lacking. This study is intended to demonstrate that early, compared with delayed, introduction of STN DBS is more beneficial for PD patients who have developed motor complications.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Chen Ling
• Collaborators: Prince of Wales Hospital, Shatin, Hong Kong; Shenzhen Second People's Hospital
• Last Updated: 2016-08-08

Criteria

Inclusion Criteria:

• Idiopathic Parkinson's Disease with good response to levodopa(i.e. more than 30% improvement in the MDS-UPDRS Part III score after an acute levodopa challenge)

• Presence of fluctuations and/or dyskinesias

• Age ranging from 18 to 75 years old

• Normal brain MRI

• Absence of dementia (Mini Mental State Examination ≥ 26)

• Absence of severe psychiatric diseases

• Written informed consent

Exclusion Criteria:

• Presence of severe metabolic diseases

• Severe cardiac/respiratory/renal/hepatic diseases

• Secondary parkinsonism or multiple system atrophy

• Illiteracy or insufficient language skills to complete the questionnaires

• Poor compliance and unreasonable expectation

• Women who are pregnant or breast feeding

• Simultaneous participation in another clinical trial