Effect IV Ibuprofen and Inflammatory Responses

• Status: Completed
• Trial end date: 2014-08-01
• Target enrollment: 0
• Participant gender: All

Summary

This study is being done because the investigators wish to study ways to improve recovery after surgery. Injury, including surgical injury, causes inflammation. Inflammation is the body's attempt to protect itself and to start the healing process. Some surgical complications are related to the body's natural inflammatory response. Although mainly a healing response, inflammation can also have side effects which delay recovery. The investigators wish to determine the effect of a medication known as ibuprofen on recovery. You may know ibuprofen by the name Advil or Motrin. The medication will be given through the vein prior to the start of the surgery. Three blood samples will be taken, two while the patient is under anesthesia. The subject will be asked to complete several questionnaires.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Medicine and Dentistry of New Jersey
• Treatments: Ibuprofen

Criteria

Inclusion Criteria:

• undergoing laparoscopic cholecystectomy under general anesthesia

• American Society of Anesthesiologists status of 1, 2 or 3 (as determined by the anesthesiologists)

• not pregnant of breast feeding

Exclusion Criteria:

• cognitively impaired

• using antipsychotic drugs

• chronic use of steroids or opioids

• subject has received COX inhibitors within 3 days if surgery

• subjects for whom opiates, benzodiazepines and COX inhibitors are contraindicated

• subjects with a history of bleeding disorders or peptic ulcer disease