Effect Of A Locally Delivered Probiotic Sacchraomyces Boulardii In The Management Of Chronic Periodontitis

• Status: Completed
• Trial end date: 2018-03-26
• Target enrollment: 0
• Participant gender: All

Summary

This study was carried out in the Department of Periodontology and source of patient was be from the outpatient section of Tatyasaheb Kore Dental College & Research Centre, New Pargaon. Study included the 31 patients with chronic periodontitis, with age group between 35-60 years, two interdental suprabony pockets with 5-8mm pocket depth in two different quadrants were chosen as the test site (TS) and control sites (CS). In control sites, only SRP was performed followed by placement of placebo distilled water. In test sites, SRP was followed by placement of Lyophilized saccharomyces boulardii in the pocket. S. boulardii will be delivered subgingivally by by mixing 1gm of sachet containing 250mg of lyophilized yeast with 0.5ml of distilled water this prepared paste was injected in the perio pocket with luer lock syringe and cannula .The subgingival plaque samples were collected at baseline, 4th day, 4 week for detection of p. gingivalis for microbiological analysis and clinical parameters wiere recorded at baseline and at 1 month.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Tatyasaheb Kore Dental College

Criteria

Inclusion Criteria:

1. Systemically healthy subject.

2. Presence of minimum 16 teeth.

3. Patient with generalized moderate to severe chronic periodontitis.

4. Probing depth (PD) 5-8mm.

5. Clinical Attachment Level > 4mm

Exclusion Criteria:

1. Tobacco in any form and alcoholics.

2. Pregnant and lactating mother.

3. Patients with history of systemic ailments, patients under ant-inflammatory/antibiotic/antifungal/probiotic/prebiotic 6 months prior to recruitment for study.

4. Subjects who had received periodontal treatment within the previous 6 months.

5. Aggressive periodontitis.

6. Patients with confirmed or suspected intolerance to S,boulardii derivatives will be excluded from the study.