Effect Of Intra-muscular Administration of Dexamethasone in Induction of Labour

• Status: Unknown status
• Trial end date: 2016-07-01
• Target enrollment: 0
• Participant gender: Female

Summary

ABSTRACT:

Objective: To evaluate the efficacy of dexamethasone on labor duration and to establish whether dexamethasone plays a role in shorting the duration interval between initiation of labor induction and beginning of the active phase in primigravida full-term pregnancy.

Methods: case control study included 86 primigravidae with full term pregnancy classified into two groups: The participant of Group I will receive a prefilled syringe with two milliliters (8 mg) of Dexamethasone intramuscular, and the participants of Group II will not receive Dexamethasone or any other cervical ripening agent.

Key Words: Dexamethasone;post-term pregnancy;induction of labor.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Kasr El Aini Hospital
• Treatments: BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate

Criteria

Inclusion Criteria:

• Singleton pregnancy.

• Primigravida.

• Post-term gestation i.e. 41 weeks or more.

• Sure, reliable dates.

• Favorable cervix with Bishop score of 7 or greater.

• Longitudinal lie.

• Cephalic presentation (Vertex).

Exclusion Criteria:

• Abnormal presentation.

• Multigravida.

• Multiple pregnancies.

• Active phase of labour.

• Cephalo-pelvic disproportion.

• History of any medical disorder.

• History of previous myomectomy operation.

• Known contraindication or hypersensitivity to Dexamethasone.

• Current fetal distress.

• Current maternal or fetal disorder e.g. Diabetes mellitus; Pregnancy induced hypertension, and fetal growth retardation.

• Over distended abdomen e.g. fetal macrosomia or polyhydramnios suggested by ultrasound or estimated fetal weight by expert hand.

• Significant vaginal bleeding.