Effect of 7 Days of Dosing With a 10 mg Rectal Suppository of NRL001in Patients With Faecal Incontinence
Status:
Completed
Trial end date:
2011-12-01
Target enrollment:
Participant gender:
Summary
This is a study to examine the effect of alpha adrenergic stimulation of the anal canal and
rectum on parameters affecting the control of defecation in subjects with faecal
incontinence. The study will investigate the effects of rectal suppositories containing 10 mg
NRL001 given for seven days, once daily. Rectal compliance and median anal resting pressure
will be considered the primary objective of the study. A pharmacokinetic evaluation plus
safety and tolerability assessment including monitoring of electrocardiograms (ECGs), blood
pressure and heart rate will also be evaluated as secondary objectives.