Effect of APL180 on Endothelial Function in Familial Hypercholesterolemia Patients

• Status: Withdrawn
• Trial end date: 2009-02-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will evaluate the effect of APL180 on endothelial function measured by forearm venous occlusion plethysmography in patients with familial hypercholesterolemia.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Novartis Pharmaceuticals

Criteria

Inclusion Criteria:

• Confirmed presence of familial hypercholesterolemia

• Women must be sterilized or post-menopausal

Exclusion Criteria:

• Smoking an average of greater than 10 cigarettes per day

• History of cardiac events

• Very low or high body weight

• Treatment with fibrates or niacin

• High blood triglyceride levels

Other protocol-defined inclusion/exclusion criteria may apply.