Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features
Status:
Unknown status
Trial end date:
2018-06-01
Target enrollment:
Participant gender:
Summary
NSAIDs, specifically cyclo-oxygenase (COX) inhibitors, are known to increase blood pressure
over time in non-pregnant adults, but the effect of COX-inhibitors on blood pressure in the
setting of preeclampsia have not been well studied. This study aims to assess the effect of
avoiding COX-inhibitors on postpartum blood pressure control among women diagnosed with
preeclampsia with severe features. Eligible women will be randomized to receive either
acetaminophen or ibuprofen for postpartum pain control. Both agents are first line therapies
for pain control although ibuprofen has better pain control than acetaminophen. The primary
outcome will be duration of postpartum severe-range hypertension.