Effect of Acetazolamide & Position in CSF Leakage and Collection and Wound Dehiscence

• Status: Unknown status
• Trial end date: 2015-09-01
• Target enrollment: 0
• Participant gender: All

Summary

• Purpose of study : to determine the preventive effect of acetazolamide administration, prone positioning, and the combination of both following the neurosurgical interventions in lumbosacral region for cerebrospinal fluid (CSF) leak, CSF collection and wound dehiscence.

• Sample size: 144

• intervention groups:

• Group A: Acetazolamide administration for 10 days

• Group B: prone positioning for 10 days

• Group C: Acetazolamide administration and prone positioning for 10 days

• Group D: no intervention

• Period of study: Autumn 2012 to the end of winter of 2015

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tehran University of Medical Sciences
• Treatments: Acetazolamide; Polystyrene sulfonic acid

Criteria

Inclusion Criteria:

• Untethering surgery for primary tethered cord caused by thick filum

• Lipomyelomeningocele

• Split cord malformation management

• Untethering surgery in uncomplicated Dermal sinus

• Tumors needing intradural management in lumbosacral region

• Having any other disease with similar management technique

Exclusion Criteria:

• Infected dermoid tumors

• Intramedullary abscess

• Myelomeningocele surgery and related reoperation

• Meningocele

• Presence of hydrocephalus