Effect of Acetylcholinesterase Inhibitors on the Gait of the Patients With Parkinson Disease

• Status: Unknown status
• Trial end date: 2018-12-30
• Target enrollment: 0
• Participant gender: All

Summary

Cholinergic deficiency in the brain can be related to gait and balance problems in Parkinson disease (PD). Recent clinical trials suggested a beneficial role of acetylcholinesterase inhibitors (AchEI) on gait in PD. In this study, the investigators are planning to study the influence of AchEI on a brain network for gait and balance in PD. As gait problem is prominent in postural instability and gait disturbance (PIGD) subtype, this study will focus on the patients with PIGD phenotype.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Kyung Hee University Hospital
• Treatments: Cholinesterase Inhibitors; Donepezil

Criteria

Inclusion Criteria:

• Parkinson disease diagnosed by United Kingdom Parkinson's disease Society Brain Bank Criteria

• Postural instability and gait disturbance phenotype

• Hoehn and Yahr stage ≤ 3

• Mini-Mental status examination ≥ 24

Exclusion Criteria:

• Significant motor complication affecting daily activities

• Drugs related to acetylcholine metabolism