Effect of Acute Statin Treatment in Patients Undergoing Percutaneous Coronary Intervention

• Status: Terminated
• Trial end date: 2011-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this study is to determine if one dose of simvastatin will decrease the inflammatory response to coronary intervention. Also to determine if one dose of simvastatin affects endothelial function (activity of the artery) as measured by noninvasive peripheral artery tonography.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mayo Clinic
• Collaborator: Merck Sharp & Dohme Corp.
• Treatments: Simvastatin

Criteria

Inclusion Criteria:

• Patients undergoing PCI/angiography

• No previously known side effects of statins

• Patients who sign an informed consent

• Age > 18 years old

Exclusion Criteria:

• Patients with ST elevation myocardial infarction

• Patients with cardiogenic shock

• Patients with hypersensitivity to statins

• Patients with unexplained muscle pain

• Patients with acute liver disease

• Patients receiving cyclosporine, antifungal azoles, macrolide antibiotics, niacin, fibrates> 1 quart grapefruit juice/day or nefazodone

• Patients with creatinine > 2.0

• Patients with known malignancy

• Ejection Fraction < 25%

• No coronary care unit patients

• No outpatients