Effect of Addition of Short Course of Prednisolone to Gluten Free Diet in Naive Celiac Disease Patients
Status:
Completed
Trial end date:
2010-08-01
Target enrollment:
Participant gender:
Summary
Withdrawal of gluten, the culprit antigen, is the definite treatment for celiac disease.
Weeks to months after gluten withdrawal from the diet before the clinical manifestations,
histological features start improving. Many of the adult patients are in the critical phase
where even weeks may matter especially those in their adolescence where height growth has
limited potential.
Suppression of immune system using a short course of steroid might retard the immune mediated
destruction of the villi while the effect of gluten withdrawal sets in. Steroids are known to
be effective in the management of refractory celiac disease. Therefore, the investigators
hypothesized that addition of a short course of steroid to gluten free diet may enhance
intestinal mucosal recovery and thus clinical manifestations
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
All India Institute of Medical Sciences, New Delhi